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Active substance: mercaptopurine (mercaptopurine). Pharmachologic effect: Purinethol has antitumor and immunosuppressive effects. It is a competitive antagonist of purine bases. Indications for use: acute lymphoblastic leukemia; acute myeloid leukemia; chronic myeloid leukemia (induction of remission and maintenance therapy). Purinethol can be used both as monotherapy and in conjunction with other cytostatic in numerous dosages, depending on the therapy program. Normally for children and adults, the dose is 50-75 mg / m2 or 2.5 mg / kg / day; Later, every day Purinethol medication dosage is adjusted based on the effect. At first signs of severe leukopenia, it is recommended to interrupt the ingestion for 2-3 days. If leukopenia does not intensify during this time period of time, the treatment is started again. In elderly sufferers, it is recommended to monitor hard working liver and renal system function. If warning signs of renal or hepatic failing are detected, the dosage ought to be decreased. The the dose also need to be lowered for patients with hepatic and / or renal deficiency.When combined with allopurinol, the dose of Mercaptopurine is reduced to 25% of the common dosage, since allopurinol reduces the metabolic rate of Mercaptopurine. Get Purinethol without prescription on the internet at the finest price tag. Unwanted effects. From the side of hematopoiesis: generally - leukopenia, thrombocytopenia, anemia. Reactions from the body's defence mechanism: hypersensitivity reactions: hardly ever - arthralgia, skin rash, drug fever; seldom - puffiness. On the digestive tract part: usually - nausea, vomiting, anorexia, intrahepatic cholestasis, hepatotoxicity (hepatotoxicity has a toxic-allergic genesis and takes place when the suggested dosage of 2.5 mg / kg / day or 75 mg / m2 / day is exceeded; hardly ever - ulceration of the oral mucosa, diarrhea, pancreatitis, hepatonecrosis; rarely - ulceration of the digestive tract mucosa. Other: decreased defense, accession of secondary infections, skin hyperpigmentation; hyperuricemia and nephropathy due to tumor lysis; almost never - the introduction of secondary leukemia, myelodysplasia and hepatolienal T-cell lymphoma. Click the web page link for Additional information on Purinethol France and best spot to get for more info
Advisable limitations for use are the following: being pregnant; lactation period, sensitivity to Mercaptopurine or other components of the drug. Over dose signs: immediate - feeling sick, nausea or vomiting, anorexia, diarrhea; postponed - myelosuppression, hardworking liver disorder, gastroenteritis. Special recommendations! Purinethol ought to be used only under doctor’s guidance and the doctor really should have experience in the usage of cytostatics. Treatment should be executed under professional medical guidance. Don't hesitate to follow the url for more info about Mercaptopurine France and finest website to buy Purinethol Without Prescription for affordable.